Bcl3 regulates pro-survival and pro-inflammatory gene.
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ACGIH Threshold Limit Values (TLVs) Little Pro on 2015-12-30 Views: Update:2019-11-16. Threshold Limit Values (TLVs) refer to airborne concentrations of chemical substances and represent conditions under which it is believed that nearly all workers may be repeatedly exposed, day after day, over a working lifetime, without adverse effects.
Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis Daniel Kreisel, 1,2 Seiichiro Sugimoto, 1 Jeremy Tietjens, 1 Jihong Zhu, 1 Sumiharu Yamamoto, 1 Alexander S. Krupnick, 1 Ruaidhri J. Carmody, 3 and Andrew E. Gelman 1,2.
Abstract. Bcl3 is a putative proto-oncogene deregulated in hematopoietic and solid tumors. Studies in cell lines suggest that its oncogenic effects are mediated through the induct.
BCL3 BCL3 A gene on 19q13.1-q13.2, which encodes a protein that functions as a transcriptional co-activator which acts by associating with NF-kappa B homodimers. BCL3’s protein product contains 7 ankyrin repeats similar to those found in I kappa B; BCL3 may interfere with binding of 50-kD subunit of NF kappa B to DNA.
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Bcl3 is a putative proto-oncogene deregulated in hematopoietic and solid tumors. Studies in cell lines suggest that its oncogenic effects are mediated through the induction of proliferation and inhibition of cell death, yet its role in endogenous solid tumors has not been established. Here, we address the oncogenic effect of Bcl3 in vivo and describe how this Stat3-responsive oncogene promotes.